

The Loewe additivity has been used as a universal reference model for classifying drug interaction. These definitions of drug interaction suggest that a zero interaction model should exist to be used as a reference in classifying the interaction of drug combinations. There are 3 classes of drug interaction: additive, synergistic, and antagonistic.
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Tel: 82-5, Fax: 82-5, 5 2010 29 5 2010 58 5 421 434 26 4 2010 29 4 2010 29 4 2010 Copyright © The Korean Society of Anesthesiologists, 2010 2010 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Īnesthesiologists have been aware of the importance of optimal drug combination long ago and performed many investigations about the combined use of anesthetic agents. Corresponding author: Soo-il Lee, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Dong-A University Medical College, 3-1, Dongdaesin-dong, Seo-gu, Busan 602-715, Korea. Korean J Anesthesiol KJAE Korean Journal of Anesthesiology 2005-6419 2005-7563 The Korean Society of Anesthesiologists 20532049 2881515 10.4097/kjae.2010.58.5.421 Review Article Drug interaction: focusing on response surface models Lee Soo-il Department of Anesthesiology and Pain Medicine, Dong-A University Medical College, Busan, Korea.
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This may include steroid creams to relieve skin rashes or antibiotics to cure skin infections.Korean Journal of Anesthesiology Introduction Your healthcare provider can prescribe treatments that will help you manage symptoms. Some conditions that can cause blisters, such as pemphigus, don’t have a cure. If there is a known cause for the blisters, such as contact with a certain chemical or use of a drug, discontinue use of that product. In addition to medication for the infection, your healthcare provider may be able to give you something to treat the symptoms. If you suspect you have some type of infection, you should see your healthcare provider. The blisters caused by infections are also temporary, but they may require treatment. In these cases, the best treatment is to avoid what is causing your skin to blister. Blisters caused by friction, allergens, and burns are temporary reactions to stimuli. You shouldn’t puncture a blister unless it is very painful, as the skin over the fluid protects you from infection. Eventually the fluids will seep back into the tissue, and the blister will disappear. If you know the cause of your blister, you may be able to treat it by covering it with bandages to keep it protected.

If you leave them alone, they will go away, and the top skin layers prevent will infection. A few skin conditions that cause blisters include: For many of these rare conditions, the cause is unknown. More rarely, blisters are the result of a skin condition.


This includes burns from heat, chemicals, and sunburns.
